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[[File:Diphenhydramine.png|300px|thumb|left]]
'''Benadryl (diphenhydramine)''' is a first-generation antihistamine that should ''never'' be given PO and ''only'' be given IV in high doses and quickly, especially if a patient asks for it because [[Waaaaambulance|life is making him or her itchy]].<ref>[http://gomerblog.com/2016/04/turkey-sandwich-dilaudid-benadryl-turlaudidryl-special/ Patients Love New Turkey Sandwich with Dilaudid & Benadryl: The Turlaudidryl Special]</ref>