Percocet (Acetaminophen-Oxycodone)

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Once paired with Tylenol, oxycodone is rendered completely ineffective

Percocet, which is a combination of the opioid oxycodone and the antiinflammatory acetaminophen, is an ineffective pain medication according to hospitalized patients because it has Tylenol in it and therefore doesn't work[1]. Interestingly, Percocet seems effective in the outpatient setting. When Percocet is offered out of a bowl in emergency rooms, the number of visits paid to the health care system drops substantially[2]. Patients in the outpatient setting have more Percocet than they know what to do with, which has explained the success of Pez Percocet dispensers[3]. They health care practitioners don't love Percocet, they certainly prefer it to the much more despised Dilaudid.

Related Reading


  1. Commentary: Percocet Doesn’t Work for Me Because It Has Tylenol, and Tylenol Doesn’t Help My Pain
  2. ER Places Bowl Full of Percocet in Waiting Room, Lowers Visits
  3. Pez Introduces New Pocket Percocet Dispenser

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